Fig. 1. Functional groups and protein-protein interactions of proteins identified in control, HR, and NecroX-5 treated rat hearts.

(A) A Venn diagram illustrates all possible logical relationships between proteins identified in control, HR, and NecroX-5 rat hearts. (B) A protein-protein interaction network built on identified proteins illustrates their proposed interactions in various cellular processes. (C) Functional protein groups were determined by interactive merging of initially defined groups based on the number or percentage of genes provided per term. (D) Identified proteins are presented based on their molecular functions in up- and down-regulated biological processes (Bonferonni corrected p-values).