Table 3.
Morphometric data.
| Control (n = 6) LVEF > 60% |
Group (I) (n = 10) LVEF 50–45% |
Group (II) (n = 15) LVEF 41–30% |
Group (III) (n = 15) LVEF < 30% |
|
|---|---|---|---|---|
| Myocyte cross-sectional area [μm2] | 415 ± 48 | 452 ± 83 | 548 ± 94 | 526 ± 127 |
| Myocyte longitudinal area [µm2] | 1294 ± 146 | 1642 ± 198∗ | 2094 ± 458∗ | 2298 ± 477∗# |
| Myocyte degeneration [%] | 0.28 ± 0.1 | 1.25 ± 0.9 | 6.72 ± 3.5 | 10.23 ± 4.6 |
| Desmin dominated pattern | I | IIA | IIB | III |
| Myocyte death | ||||
| Apoptotic [‰] | 0 | 0.03 ± 0.004 | 0.05 ± 0.008 | 0.02 ± 0.001 |
| Autophagic [‰] | 0.4 ± 0.02 | 1.01 ± 0.8 | 3.5 ± 2.18 | 7.92 ± 2.39 |
| Glycogen storage (final score) | Normal | Low | Severe | Moderate |
| Ultrastructural pathology (final score) | No | Mild | Moderate | Severe |
∗ p < 0.05 versus control group, # p < 0.05 versus Group (I).