Table 1. AUROC performance of predicting RBP binding sites.
| RNA-binding protein | GraphProt | mDBN- | mDBN+ |
|---|---|---|---|
| ALKBH5 PAR-CLIP | 0.680 | 0.686 | 0.714 |
| C17ORF85 PAR-CLIP | 0.800 | 0.817 | 0.820 |
| C22ORF28 PAR-CLIP | 0.751 | 0.783 | 0.792 |
| CAPRIN1 PAR-CLIP | 0.855 | 0.825 | 0.834 |
| Ago2 HITS-CLIP | 0.765 | 0.805 | 0.809 |
| ELAVL1 HITS-CLIP | 0.955 | 0.964 | 0.966 |
| SFRS1 HITS-CLIP | 0.898 | 0.927 | 0.931 |
| HNRNPC iCLIP | 0.952 | 0.961 | 0.962 |
| TDP43 iCLIP | 0.874 | 0.874 | 0.876 |
| TIA1 iCLIP | 0.861 | 0.888 | 0.891 |
| TIAL1 iCLIP | 0.833 | 0.867 | 0.870 |
| Ago1–4 PAR-CLIP | 0.895 | 0.872 | 0.881 |
| ELAVL1 PAR-CLIP (B) | 0.935 | 0.956 | 0.961 |
| ELAVL1 PAR-CLIP (A) | 0.959 | 0.965 | 0.966 |
| EWSR1 PAR-CLIP | 0.935 | 0.964 | 0.966 |
| FUS PAR-CLIP | 0.968 | 0.979 | 0.980 |
| ELAVL1 PAR-CLIP (C) | 0.991 | 0.994 | 0.994 |
| IGF2BP1-3 PAR-CLIP | 0.889 | 0.872 | 0.879 |
| MOV10 PAR-CLIP | 0.863 | 0.831 | 0.854 |
| PUM2 PAR-CLIP | 0.954 | 0.965 | 0.971 |
| QKI PAR-CLIP | 0.957 | 0.981 | 0.983 |
| TAF15 PAR-CLIP | 0.970 | 0.980 | 0.983 |
| PTB HITS-CLIP | 0.937 | 0.879 | 0.983 |
| ZC3H7B PAR-CLIP | 0.820 | 0.786 | 0.796 |
mDBN- stands for the multimodal DBN that only integrates the RNA base sequence and secondary structural profiles, while mDBN+ stands for the framework that integrates the RNA base sequence, secondary and tertiary structural profiles. The reported AUROC score was averaged over the 10-fold cross-validation process. The AUROC scores dropped by >2% after eliminating RNA 3D structural information are noted in bold.