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. 2015 Nov 20;44(4):1591–1612. doi: 10.1093/nar/gkv1135

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Post translational modifiation sites (PTMs) in IDRs of Mediator complex subunits of model organisms. (A) Phosphorylation and acetylation sites. (B) Methylation and glycosylation sites in the IDRs of Mediator complexes of S.cerevisiae (YEAST), A. thaliana (ARATH), O. sativa subsp. Japonica (ORYSJ), C. elegans (CAEEL), D. melanogaster (DROME), D. rerio (DANRE), G. gallus (CHICK) and H. sapiens (HUMAN). (C) PTM hotspots in the Mediator subunits. Mediator subunits (gray line) with highly conserved or moderately conserved IDRs (red bars) are shown. PTM hotspots with a density of 0.2–0.3 are shown in blue while, hotspots with a density of 0.1–0.2 are shown in black.