Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 20;44(4):1591–1612. doi: 10.1093/nar/gkv1135

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Direct interactions for human and yeast Mediator complex subunits. (A) Number of direct inter-subunit interactions reported for human and yeast Mediator complex. Dashed line represents the arbitrary threshold of five direct interactions which defines a ‘hub’. (B) Number of direct interactions of a given Mediator subunit reported in human and yeast. Dashed horizontal line corresponds to 10 interactions, a threshold to define ‘hub’ subunit. Disordered hubs with highest number of direct interactions in (C) human Med1 and (D) yeast Med17 are shown. The interaction maps contain nuclear hormone receptors (yellow triangles), general and specific transcription factors (triangles), enzymes (diamonds), polymerase subunits (parallelograms), histone proteins (round rectangles), transcription coactivators, repressors and cofactors (vee), ubinquitinylation complex proteins (octagon) and other proteins (rectangles). The networks contain both upstream and downstream interaction partners.