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. 2015 Nov 3;44(4):1613–1629. doi: 10.1093/nar/gkv1151

Figure 8.

Figure 8.

Proposed mechanistic model showing restriction of HIV-1 by HspBP1. Left, HIV-1 infection causes down-modulation of HspBP1 expression. Therefore, HspBP1 cannot inhibit HIV-1 production, consequently leading to efficient virus production. Right, when HspBP1 is over-expressed in an infected cell, HspBP1 interacts with NF-κB enhancer region (κB sites) on the HIV-1 LTR promoter and inhibits LTR driven gene-expression. The binding of HspBP1 to κB sites obliterates the binding of NF-κB hetero-dimer (p50/p65) to the same region, leading to repression in HIV-1 transcription.