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. 2015 Dec 28;44(4):1944–1951. doi: 10.1093/nar/gkv1517

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Interaction of eIF-5A with the yeast 80S ribosome. (A) View of the NTE of eIF-5A sandwiched between ribosomal proteins uL1 (blue) and eL42 (tan). (B) Domain II (DII, orange) of eIF-5A inserts into the cleft between domains 1 and 2 of uL1 (blue). (C) Comparison of the ribosome binding position of domain I of eIF-5A (red), P-tRNA (green) and 25S rRNA helix 74 (H74, blue) relative to the EF-P, P-tRNA and H74 (gray) from the bacterial EF-P–70S complex (16). Arg27 of eIF-5A makes a potential hydrogen bond interaction (dashed line) with the P-tRNA (green). (D) Possible hydrogen bond interactions (dashed lines) between domain I of eIF-5A (red) with 25S rRNA nucleotides within helices H74, H80 and H93 of the ribosome (gray).