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TCDS disbalance in the supercoiling sensitive genes is due to an orientation bias of neighboring genes. (A) Mean log ratio of the number of genes with positive and negative TCDS contribution on target gene TCDS level within a range of 10 kb in the sets of hyp, rel and none (neither hyp, nor rel). Error bars (SEM) are indicated. (B) Scheme of the preferred orientations of hyp and rel gene neighbors.
