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. 2016 Jan 14;44(4):1496–1501. doi: 10.1093/nar/gkw012

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Model for ATRX/DAXX/H3.3 in maintaining heterochromatin. (A) Heterochromatic regions such as telomeres, IAP LTRs and methylated imprinted DMRs are distributed throughout the genome and enriched for H3K9me3. (B) ATRX recognises H3K9me3 and acts with DAXX to deposit H3.3 to replace histones which are lost. DAXX interacts with KAP1 and SETDB1 to catalyse K9me3 on newly deposited H3.3. ATRX/DAXX/H3.3 are able to act continuously through the cell cycle to ensure constant maintenance of H3K9me3 heterochromatin.