. Author manuscript; available in PMC: 2016 Feb 29.

Published in final edited form as: Circ Cardiovasc Genet. 2015 Mar 3;8(3):447–456. doi: 10.1161/CIRCGENETICS.114.000785

Table 2.

Effect of KCNH2 Mutation Type and Location on the QTc-Interval

Mutation Type and Location	Patient Set 1, n=353	QTc-Interval (ms)	Patient Set 1+Set 2, n=639	QTc-Interval (ms)
Nonsense, frameshift, large deletions and insertions, all locations	150 (42%)	466±40	277 (43%)	463±40
Missense, N terminus	77 (22%)	460±49	150 (23%)	458±47
Missense, transmembrane S1–S4	11 (3%)	522±48	25 (4%)	496±55
Missense, transmembrane S5-loop-S6	86 (24%)	474±40	132 (20%)	474±40
Missense, C terminus	29 (8%)	455±32	55 (9%)	462±46

QTc indicates corrected QT.