Table 2.
Mutation Type and Location | Patient Set 1, n=353 | QTc-Interval (ms) | Patient Set 1+Set 2, n=639 | QTc-Interval (ms) |
---|---|---|---|---|
Nonsense, frameshift, large deletions and insertions, all locations | 150 (42%) | 466±40 | 277 (43%) | 463±40 |
Missense, N terminus | 77 (22%) | 460±49 | 150 (23%) | 458±47 |
Missense, transmembrane S1–S4 | 11 (3%) | 522±48 | 25 (4%) | 496±55 |
Missense, transmembrane S5-loop-S6 | 86 (24%) | 474±40 | 132 (20%) | 474±40 |
Missense, C terminus | 29 (8%) | 455±32 | 55 (9%) | 462±46 |
QTc indicates corrected QT.