Table 6.
Effect on Event-Free Survival* | Effect on Event-Free Survival in Patients With QTc<500 ms* | ||||||
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|
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SNP | Closest Gene | Major Allele | Minor Allele | RR (95% CI) | P Value† | RR (95% CI) | P Value† |
rs10494366 | N0S1AP | T | G | 1.30 (1.04–1.61) | 0.020 | 1.35 (1.04–1.77) | 0.027 |
rs12029454 | N0S1AP | G | A | 1.37 (1.08–1.74) | 0.011 | 1.45 (1.07–1.95) | 0.015 |
rs12143842 | N0S1AP | C | T | 1.14 (0.91–1.42) | 0.246 | 1.13 (0.86–1.48) | 0.373 |
rs16857031 | N0S1AP | C | G | 1.03 (0.78–1.35) | 0.855 | 0.93 (0.66–1.32) | 0.694 |
rs4657178 | N0S1AP | C | T | 1.22 (0.97–1.53) | 0.08 | 1.32 (1.00–1.74) | 0.06 |
rs2880058 | N0S1AP | A | G | 1.16 (0.94–1.44) | 0.167 | 1.22 (0.95–1.57) | 0.118 |
rs1805128 | KCNE1 | G | A | 1.33 (1.01–1.76) | 0.044 | 1.29 ((0.89–1.85) | 0.174 |
rs2074238 | KCNQ1 | C | T | 0.83 (0.53–1.31) | 0.422 | 0.78 (0.46–1.32) | 0.356 |
rs12576239 | KCNQ1 | C | T | 1.13 (0.86–1.48) | 0.38 | 1.02 (0.74–1.42) | 0.89 |
rs17779747 | KCNJ2 | G | T | 1.14 (0.92–1.42) | 0.221 | 1.21 (0.94–1.55) | 0.137 |
rs8049607 | LITAF | C | T | 0.91 (0.74–1.14) | 0.42 | 0.93 (0.73–1.20) | 0.59 |
rs2478333 | Intergenic | C | A | 1.04 (0.83–1.31) | 0.73 | 1.05 (0.82–1.34) | 0.70 |
CI indicates confidence interval; GWAS, genome-wide association study; LQT2, long-QT 2; QTc, corrected QT; RR, relative risk; and SNPs, single-nucleotide polymorphisms.
The coded allele is the minor allele.
P values for nominally associating SNPs are displayed in italics.