Table 6.

Effect of SNPs on Event-Free Survival in Sets 1 and 2 Combined

				Effect on Event-Free Survival*		Effect on Event-Free Survival in Patients With QTc<500 ms*
SNP	Closest Gene	Major Allele	Minor Allele	RR (95% CI)	P Value†	RR (95% CI)	P Value†
rs10494366	N0S1AP	T	G	1.30 (1.04–1.61)	0.020	1.35 (1.04–1.77)	0.027
rs12029454	N0S1AP	G	A	1.37 (1.08–1.74)	0.011	1.45 (1.07–1.95)	0.015
rs12143842	N0S1AP	C	T	1.14 (0.91–1.42)	0.246	1.13 (0.86–1.48)	0.373
rs16857031	N0S1AP	C	G	1.03 (0.78–1.35)	0.855	0.93 (0.66–1.32)	0.694
rs4657178	N0S1AP	C	T	1.22 (0.97–1.53)	0.08	1.32 (1.00–1.74)	0.06
rs2880058	N0S1AP	A	G	1.16 (0.94–1.44)	0.167	1.22 (0.95–1.57)	0.118
rs1805128	KCNE1	G	A	1.33 (1.01–1.76)	0.044	1.29 ((0.89–1.85)	0.174
rs2074238	KCNQ1	C	T	0.83 (0.53–1.31)	0.422	0.78 (0.46–1.32)	0.356
rs12576239	KCNQ1	C	T	1.13 (0.86–1.48)	0.38	1.02 (0.74–1.42)	0.89
rs17779747	KCNJ2	G	T	1.14 (0.92–1.42)	0.221	1.21 (0.94–1.55)	0.137
rs8049607	LITAF	C	T	0.91 (0.74–1.14)	0.42	0.93 (0.73–1.20)	0.59
rs2478333	Intergenic	C	A	1.04 (0.83–1.31)	0.73	1.05 (0.82–1.34)	0.70

CI indicates confidence interval; GWAS, genome-wide association study; LQT2, long-QT 2; QTc, corrected QT; RR, relative risk; and SNPs, single-nucleotide polymorphisms.

^*The coded allele is the minor allele.

^†P values for nominally associating SNPs are displayed in italics.