Table 1.

Plasma glucose and plasma insulin levels under 6 h fasting and (A) basal conditions (B) insulin-stimulated conditions (Insulin: 15 mU/kg/min 4 ng/ml of insulin, (C) insulin-stimulated conditions (Insulin: 25 mU/kg/min 10 ng/ml of insulin, in control and gys1-KO mice. Data shown are pooled mean ± SEM (*p < 0.05 vs. control n = 6–8 per group). –SSA: Steady State Average (Average of results from blood samples at 90′, 100′, 110′).

Condition	6-hour Fasting		Basal turnover
Group	CONTROL	gys1-KO	CONTROL	gys1-KO
Plasma glucose (mmol/l)	8.21 ± 0.60	9.26 ± 0.85	5.82 ± 0.32	5.63 ± 0.34
Plasma insulin (ng/ml)	0.48 ± 0.06	0.64 ± 0.13	0.41 ± 0.07	0.88 ± 0.26*

Hyperinsulinaemic-euglycaemic clamp – Insulin:15mU/kg/min
Condition	6-hour Fasting		Clamp (SSA)
Group	CONTROL	gys1-KO	CONTROL	gys1-KO
Plasma glucose (mmol/l)	9.90 ± 0.38	12.01 ± 0.95	9.24 ± 0.47	8.90 ± 0.49
Plasma insulin (ng/ml)	0.89 ± 0.19	1.16 ± 0.20	3.82 ± 0.47	3.42 ± 0.42

Hyperinsulinaemic-euglycaemic clamp – Insulin:25mU/kg/min
Condition	6-hour Fasting		Clamp (SSA)
Group	CONTROL	gys1-KO	CONTROL	gys1-KO
Plasma glucose (mmol/l)	10.91 ± 1.21	11.26 ± 0.73	11.25 ± 0.84	10.57 ± 0.14
Plasma insulin (ng/ml)	1.01 ± 0.28	1.59 ± 0.18	10.71 ± 0.60	9.90 ± 1.57