Figure 8. Levels of peptidoglycan biosynthesis metabolites and choline in A. baumannii.

(A) Peptidoglycan synthesis pathway of A. baumannii. Metabolites in the red box indicate metabolites that were less than 2-fold higher in polymyxin-resistant strains than polymyxin-susceptible strains. The blue and bold boxes indicate metabolites that were at least 2-fold lower in polymyxin-resistant strains than polymyxin-susceptible strains. Metabolites in the blue box indicate less than 2-fold lower abundance in polymyxin-resistant strains than polymyxin-susceptible strains. The green box indicates metabolites that were detected but not significant. Metabolites in the black box were not detected. (B) Intracellular and footprint (extracellular) choline shows significantly lower abundance in the polymyxin-resistant 19606R than the parent wild-type ATCC 19606. *p < 0.05; **p < 0.01.