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. 2016 Feb 29;6:22244. doi: 10.1038/srep22244

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(A) The DNA binding sequences (red or green) and spacer region (black) for TALENs are located in the 17 exon of APP₇₇₀. (B) The cDNA sequences of the app locus from app^Δ36; “-” denotes deleted nucleotides. (C) Sequence of deleted region in app^Δ36 (amino acids stricken-through). Sequence in the gray box represents TM region. Bolded sequence represents AICD region. The arrow indicates α, β, γ, and ε secretase sites.