Figure 2. Time-related prevalence of Abs directed against the homologous epitopes and classical islet autoantibodies in children at risk for T1D.

(A) Three time-point variations in Abs reactivity to the following peptides were analyzed: MAP3865c_133–141 (M1); ZnT8_186–194 (Z1); MAP3865c_125–133 (M2); ZnT8_178–186 (Z2), MAP1,4αgbp_157–173 (M3); PI_64–80 (P3); MAP2404c_70–85 (M4); PI_46–61 (P4). MAP/ZnT8 homologs are indicated by black lines, while gey lines indicate MAP/PI homologous epitopes. (B) Time-dependent classical Abs status evaluated including ZnT8, GADA, IAA and IA2A in 13 at-risk subjects.