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. 2015 Jun 9;156(10):2001–2012. doi: 10.1097/j.pain.0000000000000260

Figure 4.

Figure 4

Effects of ACEA and JWH133 in nociceptive, affective, and cognitive behaviors in osteoarthritic mice. Mechanical nociceptive responses in the ipsilateral paw (A and D), anxiety-like behavior (B and E), and memory (C and F) were evaluated 60, 45, and 30 minutes, respectively, after the intraperitoneal administration of ACEA or JWH133, at 1 and 3 weeks after monosodium iodoacetate or saline injection. Data are expressed as mean ± SEM (n = 15-20 per group). ★P < 0.05, ★★P < 0.01, ★★★P < 0.001 vs saline injection (Fisher LSD test); ☆P < 0.05, ☆☆P < 0.01, ☆☆☆P < 0.001 vs vehicle administration (Fisher LSD test); ###P < 0.001 vs 1 mg/kg dose (Fisher LSD test).