Figure 7.
Plasmatic endocannabinoid quantification (A) and CB1R and CB2R gene expression in the lymphocytes (B) of patients with osteoarthritis and healthy volunteers. Data are expressed as mean ± SEM (n = 14-16 per group). ★P < 0.05, ★★P < 0.01 vs healthy volunteers (Student t test). Pearson correlations between 2-AG levels and knee pain (Huskisson scale), HAD_Depression, SF-36, and visual memory scores (C) as well as correlations between CB1R or CB2R gene expression and HAD_Depression and pain scores (Huskisson scale), respectively, are presented (D). HAD, Hospital Anxiety–Depression scale.