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. 2015 Jun 19;156(10):2052–2060. doi: 10.1097/j.pain.0000000000000269

Figure 3.

Figure 3

Spinal L-291 decreases C-fiber-evoked responses and postdischarge of wide dynamic range (WDR) neurons. (A-H) Effects of spinal application of L-291 (1.2 μg (0.1 mM), n = 9; 12 μg (1 mM), n = 9; 120 μg (10 mM), n = 6) or L-456 (120 μg, n = 8) on (A-C) afferent-evoked responses, (D) postdischarge, (E) input, and (F) windup of WDR neurons, induced by transcutaneous electrical stimulation of the hind paw. White bars represent predrug control. Data are presented as mean ± SEM of predrug control responses; *P < 0.05, **P < 0.01 vs predrug control, 1-way repeated-measure analysis of variance followed by Bonferroni's posttests. (G, H) Examples of windup of single WDR neurons after repetitive electrical stimulation in the presence of spinal (G) L-291 (1.2 and 12 μg) or (H) L-456 (120 μg).