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. Author manuscript; available in PMC: 2016 Feb 29.
Published in final edited form as: Adv Enzyme Regul. 2009 Jan 3;49(1):87–96. doi: 10.1016/j.advenzreg.2008.12.008

Fig. 3.

Fig. 3

The phosphotransferase activity of ITPK1. The graphic illustrates the proposed enzymatic reactions by which the 1-phosphate on Ins(1,3,4,5,6)P5 (coloured red) is transferred to Ins(1,3,4)P3. The evidence for this reaction pathway came from HPLC analysis of the reaction products following the metabolism of [1-32P]-Ins(1,3,4,5,6)P5 by ITPK1 (Chamberlain et al., 2007). It has not yet been established whether or not a phosphoryl-enzyme (E–P) intermediate is involved, but this is a likely possibility.