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. Author manuscript; available in PMC: 2016 Aug 19.

Published in final edited form as: Bioconjug Chem. 2015 Aug 3;26(8):1413–1438. doi: 10.1021/acs.bioconjchem.5b00327

A: Selected microscopic images (Magnification: 400×) of living U87MG glioma cells stained with FITC-Galacto-RGD₂ in the absence (left) and presence (right) of excess RGD₂. B: Microscopic images (Magnification: 200×) of a tumor slice stained with FITC-Galacto-RGD₂ in the absence (left) and presence (right) of excess RGD₂. The cellular and tumor staining data were from reference 183. C: Comparison of organ uptake (%ID/g) for ^99mTc-2P-RGD₂ in the absence or presence of excess RGD₂ at 60 min p.i. D: The 60-min planar images of the tumor-bearing mice administered with ^99mTc-3P-RGD₂ in the absence/presence of RGD₂. Co-injection of excess RGD₂ resulted in significant reduction in the uptake of ^99mTc-3P-RGD₂ in both tumor and normal organs. The biodistribution and imaging data were obtained from reference 35.

A: Selected microscopic images (Magnification: 400×) of living U87MG glioma cells stained with FITC-Galacto-RGD₂ in the absence (left) and presence (right) of excess RGD₂. B: Microscopic images (Magnification: 200×) of a tumor slice stained with FITC-Galacto-RGD₂ in the absence (left) and presence (right) of excess RGD₂. The cellular and tumor staining data were from reference 183. C: Comparison of organ uptake (%ID/g) for ^99mTc-2P-RGD₂ in the absence or presence of excess RGD₂ at 60 min p.i. D: The 60-min planar images of the tumor-bearing mice administered with ^99mTc-3P-RGD₂ in the absence/presence of RGD₂. Co-injection of excess RGD₂ resulted in significant reduction in the uptake of ^99mTc-3P-RGD₂ in both tumor and normal organs. The biodistribution and imaging data were obtained from reference 35.