Table 1.
Baseline characteristics according to blood pressure control
| Variable. n% | Total (n = 165 Pts) (n = 201 Limb) (n = 246 Lesion) | Controlled HTN (n = 53 Pts) (n = 66 Limb) (n = 90 Lesion) | Uncontrolled HTN (n = 112 Pts) (n = 135 Limb) (n = 156 Lesion) | P Value |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Gender (Male) | 128 (77.5) | 43 (81.1) | 85 (75.8) | 0.550 |
| Age (years) | 68.2 ± 9.3 | 68.8 ± 10.2 | 67.9 ± 8.8 | 0.549 |
| Body mass index (kg/m2) | 23.2 ± 3.2 | 22.9 ± 3.4 | 23.3 ± 3.1 | 0.471 |
| Diagnosis | ||||
| Wound | 135 (81.8) | 44 (83) | 91 (81.2) | 0.783 |
| Diabetic foot ulcer | 124 (75.1) | 41 (77.3) | 83 (74.1) | 0.652 |
| Gangrene | 11 (6.6) | 3 (5.6) | 8 (7.1) | 1.000 |
| Claudication | 12 (7.2) | 5 (9.4) | 7 (6.2) | 0.525 |
| Resting pain | 16 (9.6) | 3 (5.6) | 13 (11.6) | 0.228 |
| Blood pressure; BP (mmHg) | ||||
| Systolic BP | 151.7 ± 17.3 | 122.6 ± 13.2 | 165.4 ± 19.2 | <0.001 |
| Diastolic BP | 76.2 ± 45.5 | 64.9 ± 12.4 | 81.5 ± 61.2 | 0.053 |
| Heart rate | 78.9 ± 14.7 | 79.1 ± 19.5 | 78.8 ± 12.4 | 0.911 |
| Pulse pressure (mmHg) | 78.6 ± 24.2 | 57.7 ± 0.8 | 83.8 ± 42.0 | <0.001 |
| Past medical and social history | ||||
| Known HTN | 116 (70.6) | 35 (66.2) | 81 (73.2) | 0.399 |
| Diabetes | 152 (92.1) | 49 (92.4) | 103 (91.9) | 1.000 |
| Dyslipidemia | 8 (4.8) | 3 (5.6) | 5 (4.4) | 0.713 |
| Cerebrovascular disease | 32 (19.3) | 9 (16.9) | 23 (20.5) | 0.676 |
| Chronic kidney disease | 55 (33.3) | 20 (37.7) | 35 (31.2) | 0.480 |
| Dialysis | 41 (24.8) | 15 (28.3) | 26 (23.2) | 0.563 |
| Atrial fibrillation | 15 (9.0) | 5 (9.4) | 10 (8.9) | 1.000 |
| Coronary artery disease | 102 (61.8) | 29 (54.7) | 73 (65.1) | 0.231 |
| Myocardial infarction | 10 (6.0) | 3 (5.6) | 7 (6.2) | 1.000 |
| PTCA | 24 (14.5) | 6 (11.3) | 18 (16.0) | 0.486 |
| CABG | 10 (6.0) | 1 (1.8) | 9 (8.0) | 0.170 |
| Smoking | 66 (40.0) | 21 (39.6) | 45 (40.1) | 1.000 |
| Current smokers | 35 (21.2) | 13 (24.5) | 22 (19.6) | 0.542 |
| Alcoholic | 49 (29.6) | 17 (32.0) | 32 (28.5) | 0.716 |
| Current alcoholics | 29 (17.5) | 11 (20.7) | 18 (16.0) | 0.513 |
| Laboratory findings | ||||
| Fasting glucose (mg/dL) | 144.2 ± 67.2 | 150.2 ± 71.9 | 141.2 ± 65.0 | 0.520 |
| Hemoglobin A1c (%) | 7.4 ± 1.4 | 7.3 ± 1.3 | 7.5 ± 1.4 | 0.318 |
| Total cholesterol (mg/dL) | 147.6 ± 44.7 | 146.6 ± 48.5 | 148.1 ± 42.9 | 0.842 |
| Triglycerides (mg/dL) | 129.6 ± 100.5 | 132.0 ± 53.0 | 128.4 ± 124.1 | 0.840 |
| HDL cholesterol (mg/dL) | 36.3 ± 11.5 | 35.9 ± 12.3 | 36.6 ± 11.2 | 0.725 |
| LDL cholesterol (mg/dL) | 90.0 ± 37.3 | 89.0 ± 38.2 | 90.5 ± 36.9 | 0.819 |
| hsCRP (mg/L) | 20.3 ± 38.6 | 25.3 ± 37.5 | 18.0 ± 39.1 | 0.439 |
| Albumin (g/dL) | 3.8 ± 1.6 | 4.1 ± 4.0 | 3.6 ± 0.5 | 0.400 |
| Uric acid (mg/dL) | 5.5 ± 1.8 | 5.6 ± 1.6 | 5.4 ± 1.8 | 0.559 |
| Creatinine (mg/dL) | 2.6 ± 3.1 | 2.8 ± 3.1 | 2.5 ± 3.0 | 0.595 |
| Magnesium (mEq/L) | 1.7 ± 0.2 | 1.7 ± 0.2 | 1.7 ± 0.3 | 0.615 |
Values are mean ± SD (range). HTN indicates hypertension group, Pts patients, AF atrial fibrillation, PTCA percutaneous transluminal coronary angioplasty, HDL high dense lipoprotein, LDL low dense lipoprotein, hs-CRP high sensitive C-reactive protein