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. 2015 Oct 19;6(36):38487–38503. doi: 10.18632/oncotarget.5750

Figure 2. Impaired immune reaction against SV40 T-Ag in NP8 mice.

Figure 2

A. Immunization protocol for SV40 (red syringe) and mKSA tumor cells (clear syringe) in the “mKSA tolerance test“. Mice mounting an immune response against T-Ag are protected against transplanted mKSA cells (“tumor rejection”), while mice with an impaired immune response die from tumor growth. B. In contrast to BALB/c mice, naïve (e.g. non-induced) NP8 mice succumb to tumor growth as a consequence of a reduced immune reaction against T-Ag presenting mKSA cells. Five mice per group (n = 5) were either infected with 105 PFU VV-941T only (○), treated with 105 mKSA cells only (▼), or a combination of 105 PFU of VV-941T and 105 mKSA cells was applied (●) total observation time was 60 days.