Table 2. MicroRNAs differentially expressed (P ≤ 0.01) between non-responders and responders to cetuximab (exploratory set of samples, N = 41).
| MicroRNA | P value | Fold change | Regulation NR/R | NR (average) | R (average) | Chromosome | Mirbase accession |
|---|---|---|---|---|---|---|---|
| miR-31-5p | 0.0002 | 14.75 | up | 3.46 | 0.23 | chr9 | MIMAT0000089 |
| miR-31-3p | 0.0018 | 6.75 | up | 1.19 | 0.18 | chr9 | MIMAT0004504 |
| miR-595 | 0.0054 | 5.56 | up | 3.83 | 0.69 | chr7 | MIMAT0003263 |
| miR-32-3p | 0.0058 | 6.73 | up | 2.79 | 0.42 | chr9 | MIMAT0004505 |
| miR-636 | 0.0093 | 2.95 | up | 5.15 | 1.74 | chr17 | MIMAT0003306 |
| miR-378a-5p | 0.0016 | 6.69 | down | 0.56 | 3.78 | chr5 | MIMAT0000731 |
| miR-192-5p | 0.0033 | 1.88 | down | 1097.67 | 2065.23 | chr11 | MIMAT0000222 |
| miR-455-5p | 0.0039 | 5.02 | down | 0.39 | 1.97 | chr9 | MIMAT0003150 |
| miR-30a-3p | 0.0061 | 4.50 | down | 0.82 | 3.7 | chr6 | MIMAT0000088 |
Regulation NR/R in the fourth column shows if the miRNA of interest is down or up regulated in non-responders compared to responders.
NR = non-responder to anti-EGFR therapy, R = responder to anti-EGFR therapy.