Table 1. Correlation of AKR1B10 expression with 14-3-3ε and clinicopathological characteristics in primary tumors of HCC patients.
| Parameters | Increase of AKR (Q-score increase ≥ 2) % (n) |
p-value |
|---|---|---|
| Overall (n = 109) | 63.3% (69) | |
| Age ≥ 60 years (n = 54) < 60 years (n = 55) |
64.8% (35) 61.8% (34) |
NS |
| Gender Male (n = 82) Female (n = 27) |
62.2% (51) 66.7% (18) |
NS |
| Histology grade 1 (n = 7) 2 (n = 78) 3 (n = 24) |
42.9% (3) 66.7% (52) 58.3% (14) |
NS |
| Types of surgery Wedge resection (n = 39) Segmentectomy (n = 53) Lobectomy (n = 17) |
69.2% (27) 60.4% (32) 58.8% (10) |
NS |
| Surgical margin Free (n = 83) Involved (n = 26) |
70.0% (58) 42.3% (11) |
0.011* |
| BCLC staging Not available (n = 3) Early (stage A1 to A4) (n = 56) Intermediate (stage B) (n = 48) Advanced (stage C) (n = 2) |
71.4% (40) 52.1% (25) 50.0% (1) |
0.042* |
| Tumor Size ≥ 5.0 cm (n = 34) < 5.0 cm (n = 75) |
52.9% (18) 68.0% (51) |
NS |
| Tumor multiplicity Single (n = 84) Multiple (n = 25) |
66.7% (56) 52.0% (13) |
NS |
| Capsular formation Not available (n = 8) Yes (n = 58) No (n = 43) |
60.3% (35) 60.5% (26) |
NS |
| Micro-vascular thrombi Yes (n = 47) No (n = 62) |
55.3% (26) 69.4% (43) |
NS |
| Liver cirrhosis Not available (n = 3) Yes (n = 56) No (n = 50) |
71.4% (40) 54.0% (27) |
0.063 |
| Viral Hepatitis Not available (n = 7) Hepatitis B (n = 54) Hepatitis C (n = 30) Both (n = 15) None (n = 3) |
59.3% (32) 53.3% (16) 80.0% (12) 100.0% (3) |
NS |
| Alpha-fetoprotein level Not available (n = 12) ≥ 80 ng/ml (n = 35) < 80 ng/ml (n = 62) |
65.7% (23) 59.7% (37) |
NS |
| Subsequent extrahepatic metastasis Yes (n = 29) No (n = 80) |
48.3% (14) 68.8% (55) |
0.047* |
| 14-3-3ε positivity Yes (n = 66) No (n = 43) |
77.3% (51) 41.9% (18) |
< 0.001* |
BCLC, Barcelona-Clinic Liver Cancer; NS, not significant; Q-score, Quick-score
*
p < 0.05