Table 2. Univariate analyses (UA) and multivariate analyses (MA) of overall survival with or without time-varying covariate (TVC).

Baseline and clinical features		UA without TVC			MA without TVC			MA with TVC
		HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
CIN	Absent	1.00			1.00			1.00
	Moderate	0.43	0.24–0.75	0.003	0.31	0.17–0.56	< 0.001	0.31	0.17–0.55	< 0.001
	Severe	0.59	0.35–1.01	0.053	0.34	0.19–0.61	< 0.001	0.36	0.20–0.64	0.001
Differentiation grade	Low/undifferentiated	1.00			1.00			1.00
	Moderate/high	0.51	0.25–1.04	0.065	0.72	0.34–1.50	0.373	0.72	0.34–1.50	0.377
	Unclassified	0.92	0.57–1.47	0.718	0.94	0.58–1.55	0.816	0.95	0.58–1.55	0.832
Liver metastasis		1.48	0.98–2.23	0.060	2.55	1.60–4.06	< 0.001	2.54	1.59–4.04	< 0.001
Lung metastasis		2.00	1.03–3.89	0.040	2.05	1.04–4.05	0.039	2.03	1.03–4.01	0.042
Ascites and/or pleural effusion		2.55	1.63–3.98	< 0.001	4.09	2.42–6.90	< 0.001	4.06	2.40–6.85	< 0.001
Baseline hemoglobin > median (120 g/L)		0.68	0.45–1.03	0.070	0.66	0.43–1.01	0.057	0.66	0.43–1.02	0.061