Table 3. Univariate analyses (UA) and multivariate analyses (MA) of progression-free survival with or without time-varying covariate (TVC).

Baseline and clinical features		UA without TVC			MA without TVC			MA with TVC
		HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
CIN	Absent	1.00			1.00			1.00
	Moderate	0.22	0.13–0.38	< 0.001	0.21	0.12–0.37	< 0.001	0.23	0.13–0.40	< 0.001
	Severe	0.25	0.15–0.42	< 0.001	0.23	0.14–0.39	< 0.001	0.29	0.17–0.50	< 0.001
Differentiation grade	Low/undifferentiated	1.00			1.00			1.00
	Moderate/high	0.34	0.16–0.74	0.007	0.51	0.23–1.15	0.105	0.52	0.23–1.16	0.110
	Unclassified	0.88	0.58–1.35	0.570	0.85	0.54–1.32	0.465	0.86	0.55–1.34	0.500
Heterochronous (relapse from radical surgery)		0.41	0.24–0.72	0.002	0.50	0.29–0.88	0.016	0.49	0.28–0.85	0.012
Ascites and/or pleural effusion		1.91	1.28–2.84	0.002	2.08	1.38–3.14	< 0.001	2.00	1.33–3.00	0.001
Baseline hemoglobin > median (120 g/L)		0.70	0.48–1.02	0.060	0.75	0.51–1.09	0.129	0.76	0.52–1.11	0.157
Baseline platelet count > median (241 × 109/L)		1.52	1.05–2.21	0.028	1.15	0.77–1.73	0.487	1.10	0.72–1.68	0.648