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Steady-state kinetic parameters for purified wild type and mutant hTH enzymes
| Enzyme form | Km, L-Tyr (μM) | Vmax, L-Tyr (nmol/min/mg) | Km, BH4 (μM) | Vmax, BH4 (nmol/min/mg) |
|---|---|---|---|---|
| hTH WT | 16.0 ± 1.8 | 42.3 ± 12.2 | 82.2 ± 15.7 | 43.6 ± 8.9 |
| hTH V81M | 32.8 ± 3.5 | 48.3 ± 15.9 | 83.0 ± 28.3 | 47.7 ± 9.9 |
| p-value | 0.0049 | 0.78 | 0.98 | 0.77 |
