Table 1.

Statistical significance of biomarker candidates ranked by Guan et al. (2012) and supported by three or more studies.

miRNA‡	Guan et al. meta-analysis†		t-test results this study
	Number of supporting studies§	Total sample size (n)	p-values (1-tailed)#	Fold change¶
miR-126 (3p)	10	587	6.0 × 10−10	−3.85
miR-210 (3p)	9	796	7.3 × 10−8	2.76
miR-486–5p††	8	563	1.7 × 10−8	−4.72
miR-21 (5p)	7	448	7.5 × 10−11	2.96
miR-182 (5p)	6	496	2.2 × 10−6	2.68
miR-31 (5p)	6	425	4.5 × 10−4	3.38
miR-451 (451a)	6	265	2.6 × 10−8	−4.30
miR-205 (5p)	5	417	5.8 × 10−5	8.10
miR-139–5p‡‡	5	371	1.9 × 10−10	−4.20
miR-200b (3p)	5	262	0.13	1.20
miR-30d (5p)	5	154	2.6 × 10−4	−1.99
miR-183 (5p)	4	388	1.4 × 10−6	2.89
miR-145 (5p)	4	362	4.7 × 10−10	−3.28
miR-143 (3p)	4	310	2.5 × 10−10	−2.73
miR-203 (203a)	3	347	0.095	1.33
miR-196a (5p)	3	317	4.0 × 10−10	11.2
miR-708 (5p)	3	301	5.2 × 10−8	3.89
miR-126* (126–5p)	3	280	0.0055	−1.82
miR-140–3p	3	179	6.4 × 10−9	−2.08
miR-138 (5p)	3	164	4.8 × 10−5	−2.33
miR-193b (3p)	3	149	2.6 × 10−4	1.89
miR-30b (5p)	3	132	4.4 × 10−4	−1.71
miR-101 (3p)	3	87	0.0026	−1.35

^†Data extracted from Tables 2 and 3 of Guan et al. [2].

^‡The miRNA names are those used by Guan et al. [2]. Updated designations according to miRBase (www.mirbase.org) are shown in parentheses.

^§The number of studies reporting significant differential expression of the miRNA in the same direction (up- or downregulated).

^#p-values < 0.00069 (6.9 × 10⁻⁴) are shown in exponential notation to indicate statistical significance (α < 0.05) in the direction expected after strict Bonferroni correction (0.05/72 miRNAs tested).

^¶Negative fold change values indicate expression levels that were lower in tumor than control.

^††The Guan et al. data for miR-486 and miR-486–5p were combined because they are the same miRNA.

^‡‡The Guan et al. data for miR-139 and miR-139–5p were combined because they are the same miRNA.