Table 2.

Statistical significance of biomarker candidates ranked by Guan et al. (2012) that were supported by two studies.

Guan et al. (2012) meta-analysis†		t-test results this study
miRNA‡	Total sample size	p-value (1-tailed)§	Fold change#
miR-106a (5p)	279	0.034	1.20
miR-125a (5p)	279	0.0058	−1.31
miR-198	273	0.42	−1.07
miR-21* (3p)	271	2.2 × 10−6	2.26
miR-144* (5p)	271	6.2 × 10−8	−4.10
miR-140 (5p)	248	1.5 × 10−7	−1.71
miR-218 (5p)	246	7.5 × 10−9	−2.82
miR-135b (5p)	222	7.0 × 10−6	2.26
miR-32 (5p)	220	(0.054)	(1.24)
miR-96 (5p)	218	5.5 × 10−4	2.19
miR-17-5p	136	0.27	1.05
miR-338 (3p)	133	1.4 × 10−4	−3.06
miR-20b (5p)	117	(0.019)	(−1.54)
miR-18a (5p)	114	0.0039	1.37
miR-200a (3p)	111	0.13	1.22
miR-93 (5p)	111	6.5 × 10−4	1.35
miR-99a (5p)	111	0.15	−1.16
miR-130b (3p)	108	4.6 × 10−10	2.99
miR-200c (3p)	101	0.0091	1.53
miR-195 (5p)	98	1.5 × 10−6	−1.93
miR-497 (5p)	98	5.9 × 10−7	−2.09
miR-30c (5p)	86	1.5 × 10−6	−1.82
miR-375	86	(0.21)	(−1.38)
miR-20a (5p)	83	0.033	1.25
miR-130a (3p)	81	0.0084	−1.39
miR-18b (5p)	80	7.3 × 10−5	1.56
miR-16 (5p)	76	3.4 × 10−6	−1.51

^†Data extracted from Tables 2 and 3 of Guan et al. [2].

^‡The miRNA names are those used by Guan et al. [2]. Updated designations according to MirBase (www.mirbase.org) are shown in parentheses.

^§p-values < 0.00069 (6.9 × 10⁻⁴) are shown in exponential notation to indicate statistical significance (α < 0.05) in the direction expected after strict Bonferroni correction (0.05/72 miRNAs tested). The three p-values in parentheses are 2-tailed and fold change was in the opposite direction from expected.

^#Negative fold change values indicate expression levels that were lower in tumor than control. Values in parentheses indicate changes that were in the opposite direction from expected.