Table 4.
Most frequent symptoms at 12 months
| Symptom | No (%) | Effect size: odds ratio* (95% CI) | P value | |
|---|---|---|---|---|
| Intensive target arm | Standard target arm | |||
| Pain | 93/163 (57) | 89/173 (51) | 1.17 (0.75 to 1.84) | 0.48 |
| Breathlessness | 53/148 (36) | 49/158 (31) | 1.17 (0.72 to 1.92) | 0.53 |
| Fatigue | 75/149 (50) | 88/163 (54) | 0.81 (0.51 to 1.28) | 0.36 |
| Stiff joints | 93/162 (57) | 99/176 (56) | 0.94 (0.59 to 1.49) | 0.80 |
| Sore eyes | 35/148 (24) | 24/158 (15) | 1.68 (0.93 to 3.04) | 0.08 |
| Wheeziness | 32/163 (20) | 28/175 (16) | 1.24 (0.70 to 2.21) | 0.46 |
| Headaches | 27/151 (18) | 36/165 (22) | 0.69 (0.38 to 1.24) | 0.22 |
| Sleep difficulties | 56/150 (37) | 66/163 (40) | 0.81 (0.51 to 1.31) | 0.39 |
| Dizziness | 45/164 (27) | 39/173 (23) | 1.24 (0.74 to 2.08) | 0.42 |
| Loss of strength | 44/148 (30) | 51/162 (31) | 0.85 (0.51 to 1.40) | 0.52 |
| Loss of libido | 47/160 (29) | 50/171 (29) | 1.06 (0.65 to 1.72) | 0.83 |
| Impotence | 29/129 (22) | 31/145 (21) | 1.22 (0.65 to 2.30) | 0.54 |
| Pins and needles | 54/163 (33) | 44/176 (25) | 1.48 (0.91 to 2.41) | 0.11 |
| Cough | 40/144 (28) | 49/160 (31) | 0.86 (0.51 to 1.44) | 0.57 |
| Swelling of legs/ankles | 51/162 (31) | 49/177 (28) | 1.10 (0.67 to 1.81) | 0.70 |
| Dry mouth | 34/147 (23) | 36/161 (22) | 0.98 (0.57 to 1.70) | 0.95 |
*Adjusted for baseline systolic blood pressure, age group (<80, ≥80 years), sex, diabetes mellitus, atrial fibrillation, and general practice (random effect).