Table 1.
Static measurements in male and female mice fed high fat diets and cholesterol plus no added PFOA (control) or added PFOA.
| C57BL/6 |
BALB/c |
|||
|---|---|---|---|---|
| Control | PFOA | Control | PFOA | |
| Male | ||||
| Body weight (g) | 26.3 ± 0.4 | 25.6 ± 0.2 | 24.8 ± 1.0 | 24.8 ± 0.4 |
| Body fat (%) | 9.4 ± 1.1 | 8.4 ± 1.1 | 10.6 ± 0.8 | 11.0 ± 1.1 |
| Liver (% body) | 5.2 ± 0.1 | 8.7 ± 0.3* | 5.5 ± 0.3 | 8.5 ± 0.4* |
| PFOA levels (ng/ml) | 2 | 26,900 | 5 | 28,200 |
| Female | ||||
| Body weight (g) | 20.4 ± 0.6 | 20.3 ± 0.5 | 20.7 ± 0.2 | 21.0 ± 0.4 |
| Body fat (%) | 10.5 ± 0.8 | 10.6 ± 0.9 | 10.1 ± 0.6 | 10.1 ± 0.5 |
| Liver (% body) | 5.6 ± 0.3 | 9.3 ± 0.7* | 5.7 ± 0.2 | 9.4 ± 0.3* |
| PFOA levels (ng/ml)a | 28 | 44,300 | 86 | 35,600 |
| Estradiol (ng/ml)b | 11.7 ± 1.8 | 8.6 ± 2.0 | 7.5 ± 1.5 | 10.8 ± 1.7 |
Note: Data are presented as means ± SEM (n = 6).
*
Significant differences from control (P < 0.05).
a
Plasma of mice within each group are pooled for PFOA levels only.
b
n = 5, 2, 4, and 4 for control C57, PFOA C57, control BALB/c, and PFOA BALB/c, respectively.