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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Plast Reconstr Surg. 2016 Mar;137(3):545e–553e. doi: 10.1097/01.prs.0000475823.01907.53

Figure 5. Ro 32-3555 Treated Mice Have Decreased Col1a1 Expression at Day 21 and Increased Mmp2 Expression at Day 28.

Figure 5

[A] RT-PCR analysis was used to assess Col1a1 expression in vehicle treated mice (black line) and Ro 32-3555 treated mice (red line) at days 3, 7, 10, 14, 21, and 28. Col1a1 expression peaked at day 21 for both groups (vehicle: 39.9-fold increase, Ro 32-3555: 22.5-fold increase, both relative to day three vehicle treatment). However, vehicle treated mice have significantly higher expression of Col1a1 at day 21 (p<0.0001). [B] Mmp2 expression was also measured in both groups, and peaks on day 21 post-repair (vehicle: 24.2-fold increase, Ro 32-3555: 27.6-fold increase, both relative to day three vehicle).