Peripheral |
Airways and lung tissue beyond the subsegmental airways |
Central |
The central airways up to and including the subsegmental airways |
xs, xsl
|
The subscript s indicates the value x changes with subject, and the subscript sl indicates that the value x changes with both subject and lobe |
 |
The specific deposition in the periphery of a lobe, the subject average specific deposition, and the non-dimensional ratio of
|
 |
The specific ventilation of a lobe, the average specific ventilation of a subject, and the non-dimensional ratio of
|
 |
The escape fractions of aerosol passing location x in inhalation of the aerosol due to impaction, sedimentation, and diffusion |
 |
The fraction of aerosol passing location x during inhalation of the aerosol that is not exhaled, that fraction for a given lobe, for a given subject, and the non-dimensional ratio of
|
 |
The retention factor of aerosol passing the carina along a pathway leading to a specific lobe, or to the entire lung |
Cx, Csl, Ccarina,s
|
The concentration of the aerosol in air at: location x in the airway tree, entering into the periphery of a given lobe, passing the carina of a given subject |
Dx, Vx |
The cumulative aerosol that deposits past location x in the airway tree during inhalation, and the cumulative volume of air that passes that location during inhalation |
Bk |
The branching factor of airway k. Describes the change of concentration between the terminus of the parent airway and the airway entrance during inhalation if the aerosol |
Ek |
The escape fraction of airway k. Describes the change of concentration along an airway k during inhalation of the aerosol |
 |
The net branching factor of a given lobe, the average for a subject, the ratio of , and this value estimated with complete retention |
 |
The net escape fraction of a given lobe, the average for a subject, the ratio of and this value estimated with complete retention |
 |
Factors of that independently effect and
|
tN,s |
The nebulization time for a given subject |
D0,s, DE,s, DT,s, DP,s, DC,s
|
The total aerosol arriving at the carina, the exhaled fraction, the total deposited, the peripheral deposition, and the central deposition of a given subject (with a subscript sl, it is of a given lobe) |
 |
The total average rate and volume of gas passing the carina of a given subject during inhalation |
VL,s |
The subject lung volume |
 |
The set of airways feeding a given lobe |
S |
The set of all lobes of all subjects |
 |
The specific inflation of a lobe, the subject average specific ventilation, and the non-dimension ratio of the
|
MLV,TLC |
The mean lung volume during tidal breathing, and total lung capacity |
 |
The total change in gas volume from the MLV to TLC HRCT image |
Ksl |
A factor that accounts for segmentation differences and the change in blood volume between the MLV to TLC HRCT images |
 |
The fraction of subjects ventilation reaching a given lobe |
ds, vs, ts
|
The distance a particle would sediment, the settling velocity, and the settling time |
QN |
The inhalation flow rate |
 |
The degree of expansion of a lobe (the gas volume/the non-gas volume) |
 |
The gas and non-gas (tissue and blood) volumes estimated for a given lobe in the MLV image. A subscript of TLC indicates that this was taken from the TLC image, and a subscript of s (or T) indicates that is volume of the entire lung |
fN |
The breathing frequency of a given subject during inhalation |
FEV1
|
Forced expiratory volume in 1 second after a deep inhalation |
FVC |
Forced vital capacity |