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. 2015 Oct 14;25(2):189–201. doi: 10.1089/scd.2015.0190

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© Yuan Hong Yu, et al., 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (<http://creativecommons.org/licenses/by-nc/4.0/>) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 7. — Single-cell messenger RNA (mRNA) profiling of LeX⁺/C1qR1⁺ and LeX⁺/C1qR1⁻ cells. (A) Forty-eight-dimensional mRNA profiling data were compressed to two dimensions by nonmetric multidimensional scaling (nMDS). Axes for the two dimensions are labeled as nMDS_1 and nMDS_2. Model-based clustering (Mclust) was then used to cluster cells based on the mRNA profile of 48 genes. Three clusters were derived—I, II, and III. Each point represents one cell. (B–D) Bar plots showing log_2-fold change in gene expression for genes that show significant change in expression (P < 0.05) in a cluster in comparison with the remaining clusters combined. (E) The ratio of LeX⁺/C1qR1⁺ cells to LeX⁺/C1qR1⁻ cells and the percentage of LeX⁺/C1qR1⁺ cells and LeX⁺/C1qR1⁻ cells in each cluster were calculated. The genes that show significant changes in expression in each cluster are shown. Passage 2 cells were used for single-cell mRNA profiling.