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Levels of inflammatory mediators for all subjects over time with depot-medroxyprogesterone acetate (DMPA)-fitted trend lines pre- and post-DMPA. A: Interleukin (IL)-1 receptor antagonist. B, IL-8. C, secretory leukocyte protease inhibitor (SLPI). D, il-6. E, Interferon-γ-inducible protein 10 (IP-10). P-values and estimates were calculated using linear mixed effects models with linear splines pre- and post-DMPA initiation (random slopes post DMPA-initiation).
