Table II.
Treatment response, relapse and survival for individual patients.
| Disease status at enrolment |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient | Haematological relapse (Y/N) |
Cytogenetic relapse (Y/N) |
Molecular relapse (Y/N) |
Haematological response |
Cytogenetic response (Y/N) |
Molecular response (Y/N) |
Relapse (Y/N) |
Time to relapse (d) |
Overall survival (d) |
Alive at last follow-up (Y/N) |
| 1 | Y | Y | Y | RD | N | N | – | – | 289 | N |
| 2* | Y | Y | Y | CR | Y | N | N | – | 257 | N |
| 3* | Y | Y | Y | CR | Y | N | N | – | 526 | N |
| 4 | Y | Y | Y | CRi | Y | N | Y | 183 | 213 | N |
| 5 | Y | Y | Y | RD | N | N | – | – | 378 | N |
| 6† | Y | Y | N/A | CR | N | Y | Y | 117 | 183 | Y |
| 7* | Y | Y | Y | CRi | Y | Y | Y | 816 | 1432 | N |
| 8 | Y | Y | N/A | RD | N | N | – | – | 154 | N |
| 9 | N | N | Y | CRi | Y | N | Y | 295 | 320 | N |
| 10 | Y | Y | Y | CR | Y | Y | Y | 49 | 233 | N |
| 11‡ | Y | Y | Y | CR | N/A | Y | Y | 56 | 1769 | Y |
| 12 | N | N | Y | CRi | N/A | N | Y | 141 | 385 | N |
| 13 | Y | Y | Y | RD | – | – | – | – | 64 | N |
| 14 | Y | Y | Y | RD | – | – | – | – | 93 | N |
Time to relapse is calculated from time of first response (CR or CRi).
CR, complete remission; CRi, complete remission with incomplete recovery of counts; RD, resistant disease; N/A, not available; Y, yes; N, no.
*
Patients 2, 3 and 7 underwent stem cell transplantation after achieving remission.
†
Patient 6 had a negative molecular test but positive cytogenetics, suggesting that this molecular result was probably not accurate.
‡
Patient 11 had an isolated central nervous system relapse which was successfully treated with IT chemotherapy and craniospinal radiation.