Table 3. Cumulative Average aMED Score and Risk of Breast Cancer by Molecular Subtype.
| aMED score | p for trend | P-het | |||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | |||
| Range | (0-2.6) | (2.7-3.5) | (3.6-4.4) | (4.5-5.4) | (5.5-9.0) | ||
| Luminal A (n=1,363) | 0.71 | ||||||
| # cases/person-years | 249/351,960 | 274/355,124 | 253/330,356 | 292/356,141 | 326/377,754 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 1.09 (0.92, 1.30) | 1.07 (0.90, 1.28) | 1.11 (0.94, 1.32) | 1.15 (0.97, 1.36) | 0.13 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 1.07 (0.89, 1.27) | 1.03 (0.86, 1.23) | 1.06 (0.89, 1.27) | 1.09 (0.91, 1.30) | 0.44 | |
| Luminal B (n=563) | |||||||
| # cases/person-years | 95/352,096 | 117/355,275 | 101/330,492 | 133/356,280 | 125/377,931 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 1.11 (0.85, 1.46) | 0.99 (0.75, 1.32) | 1.24 (0.95, 1.62) | 1.08 (0.82, 1.42) | 0.52 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 1.09 (0.83, 1.43) | 0.94 (0.70, 1.26) | 1.18 (0.89, 1.56) | 1.02 (0.76, 1.37) | 0.87 | |
| Her2 type (n=133) | |||||||
| # cases/person-years | 31/352,171 | 27/355,366 | 25/330,561 | 22/356,378 | 29/378,015 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 0.78 (0.46, 1.31) | 0.83 (0.48, 1.43) | 0.62 (0.36, 1.09) | 0.79 (0.47, 1.32) | 0.30 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 0.77 (0.45, 1.30) | 0.81 (0.47, 1.40) | 0.60 (0.33, 1.07) | 0.74 (0.42, 1.29) | 0.24 | |
| Basal-like (n=206) | |||||||
| # cases/person-years | 42/352,154 | 44/355,348 | 44/330,537 | 37/356,369 | 41/378,003 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 1.10 (0.72, 1.69) | 1.26 (0.82, 1.93) | 0.95 (0.61, 1.48) | 0.93 (0.60, 1.45) | 0.65 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 1.05 (0.68, 1.62) | 1.15 (0.74, 1.78) | 0.84 (0.53, 1.33) | 0.78 (0.49, 1.26) | 0.24 | |
| Unclassified (n=65) | |||||||
| # cases/person-years | 16/352,183 | 10/355,380 | 14/330,573 | 9/356,392 | 18/378,032 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 0.68 (0.30, 1.50) | 1.14 (0.55, 2.37) | 0.63 (0.28, 1.44) | 1.10 (0.56, 2.18) | 0.74 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 0.62 (0.28, 1.40) | 1.01 (0.48, 2.14) | 0.57 (0.24, 1.34) | 0.89 (0.41, 1.89) | 0.86 | |
a
Multivariate model adjusted for BMI at age 18 (continuous), weight change since age 18 in kgs (continuous), physical activity in MET hours/week (<3, 3-<9, 9-<18, 18-<27, 27+), energy intake in kilocalories/day (continuous), parity/age at first birth (nulliparous, 1-2 children <25 years, 1-2 children 25-29 years, 1-2 children 30+ years, 3+ children <25 years, 3+ children 25-29 years, 3+ children 30+ years), menopausal hormone use (premenopausal, postmenopausal never/past/current/unknown), oral contraceptive use (never/ever), age at menarche (<12, 12, 13, 14, 15+ years), age at menopause (continuous), family history of breast cancer (yes/no), and benign breast disease diagnosis (yes/no).