Table 4. Cumulative Average DASH Score and Risk of Breast Cancer by Molecular Subtype.
| DASH score | p for trend | P-het | |||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | |||
| Range | (7.0-19.6) | (19.7-22.2) | (22.3-24.6) | (24.7-27.0) | (27.1-38.0) | ||
| Luminal A (n=1,394) | 0.12 | ||||||
| # cases/person-years | 248/352,753 | 246/355,877 | 295/351,637 | 297/353,650 | 308/354,837 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 0.93 (0.78, 1.11) | 1.13 (0.95, 1.34) | 1.09 (0.92, 1.29) | 1.06 (0.89, 1.26) | 0.23 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 0.90 (0.75, 1.08) | 1.08 (0.91, 1.29) | 1.04 (0.87, 1.24) | 0.99 (0.83, 1.19) | 0.63 | |
| Luminal B (n=569) | |||||||
| # cases/person-years | 98/352,891 | 106/356,004 | 115/351,792 | 121/353,800 | 129/355,009 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 0.95 (0.72, 1.26) | 1.02 (0.77, 1.34) | 1.06 (0.81, 1.39) | 1.10 (0.84, 1.45) | 0.34 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 0.91 (0.69, 1.20) | 0.96 (0.73, 1.27) | 1.00 (0.76, 1.32) | 1.04 (0.78, 1.38) | 0.59 | |
| Her2 type (n=139) | |||||||
| # cases/person-years | 41/352,952 | 22/356,085 | 17/351,885 | 33/353,882 | 21/355,107 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 0.53 (0.31, 0.89) | 0.36 (0.20, 0.65) | 0.73 (0.45, 1.16) | 0.43 (0.25, 0.73) | 0.01 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 0.52 (0.31, 0.89) | 0.37 (0.21, 0.66) | 0.72 (0.45, 1.18) | 0.44 (0.25, 0.77) | 0.02 | |
| Basal-like (n=225) | |||||||
| # cases/person-years | 45/352,940 | 38/356,074 | 47/351,850 | 39/353,881 | 39/355,085 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 0.87 (0.56, 1.35) | 1.12 (0.74, 1.69) | 0.89 (0.58, 1.39) | 0.87 (0.56, 1.36) | 0.58 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 0.86 (0.55, 1.33) | 1.04 (0.68, 1.59) | 0.83 (0.53, 1.30) | 0.77 (0.48, 1.22) | 0.26 | |
| Unclassified (n=74) | |||||||
| # cases/person-years | 14/352,970 | 15/356,097 | 8/351,891 | 12/353,905 | 18/355,116 | ||
| Age-adjusted HR (95% CI) | 1.00 (ref) | 1.13 (0.54, 2.37) | 0.60 (0.25, 1.45) | 0.92 (0.42, 2.01) | 1.36 (0.66, 2.80) | 0.55 | |
| Multivariate HRa (95% CI) | 1.00 (ref) | 1.20 (0.57, 2.54) | 0.61 (0.25, 1.49) | 0.94 (0.42, 2.12) | 1.37 (0.64, 2.94) | 0.56 | |
Multivariate model adjusted for BMI at age 18 (continuous), weight change since age 18 in kgs (continuous), physical activity in MET hours/week (<3, 3-<9, 9-<18, 18-<27, 27+), energy intake in kilocalories/day (continuous), parity/age at first birth (nulliparous, 1-2 children <25 years, 1-2 children 25-29 years, 1-2 children 30+ years, 3+ children <25 years, 3+ children 25-29 years, 3+ children 30+ years), menopausal hormone use (premenopausal, postmenopausal never/past/current/unknown), alcohol intake (Nondrinker, 0.1-<5g/day, 5-<10 g/day, 10-<20g/day, 20+ g/day), oral contraceptive use (never/ever), age at menarche (<12, 12, 13, 14, 15+ years), age at menopause (continuous), family history of breast cancer (yes/no), and benign breast disease diagnosis (yes/no).