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. 2016 Jan 14;37(3):690–702. doi: 10.3892/ijmm.2016.2458

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Quercetin and temozolomide-loaded nanoliposomes (QUE/TMZ-NLs) exert cytotoxic effects on the temozolomide-resistant U87 glioma cells (U87/TR cells). (A) The relative colony formation rate of the U87/TR cells following treatment with TMZ at the indicated concentrations. (B) The effects of TMZ on the viability of U87 and U87/TR cells. (C) Cell death was measured by the release of LDH from the U87/TR cells. (D) Treatment with QUE/TMZ-NLs decreased the viability of the U87/TR glioma cells as measured by MTT Assay. ^*p<0.05, ^**p<0.01 and ^***p<0.001 compared with the control. QUE, quercetin; TMZ, temozolomide; NLs, nanoliposomes.