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. 2016 Feb 3;37(3):631–638. doi: 10.3892/ijmm.2016.2478

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Copyright: © He et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of uncoupling protein 2 (UCP2) overexpression on per meability transition pore (PTP) opening and cytochrome c release. (A) Overexpression of UCP2 in human umbilical vein endothelial cells (HUVECs) significantly delayed the time of mPTP opening compared to the adenovirus β-galactosidase (Ad-β-gal) control. (B) Western blot analysis of the release of cytochrome c from mitochondria into the cytosol. The values are presented as the means ± SD of three independent experiments. ^*P<0.01 vs. control.