Fig 5. Hierarchical clustering of the 1008 edges in the discovery set.

Three edge groups can be observed on the dendrogram: (1) positive dominant, (2) negative dominant and (3) heterogeneous. Hierarchical clustering was performed with Ward linkage and Euclidean distance. Blue and red denote negative and positive consensus edge weights respectively. The shades of green denote the recurrence of each edge, i.e. the number of tumor types (between 1 and 11) where that edge has consensus rank smaller (more significant) than the threshold of 425.