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Schematic of CD47 processing. CD47 is encoded by a short isoform and a long isoform through UTR alternative polyadenylation. RNA-binding proteins bind to the long, but not the short, isoform of CD47. After translation in the endoplasmic reticulum, localization factors are recruited to the long isoform that facilitate the transport of the encoded protein into vesicles and to the plasma membrane.
