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A) The bioisosteric carboxylic acid and tetrazolyl moieties in two Losartan derivatives;[8] B) the four lone pairs of the four nitrogen atoms of tetrazole and the two oxygen atoms of the carboxylic acid point into similar regions in space; C) receptor ligand interactions around a tetrazolate moiety in a β-lactamase (PDB ID:4DE1) showing the involvement of all four nitrogen lone pairs.[9]
