Fig 7. Treatment with 2H7 reduces the staphylococcal burden in kidneys.

BALB/c mice (female, 6-week-old, n = 9) were injected intraperitoneally with a single dose (15 mg/kg) of 2H7 or isotype control mAb 24 h prior to challenge. On day 2 following intraperitoneal challenge and day 4 following intravenous challenge, the infected mice were euthanized by CO₂ inhalation. The staphylococcal loads in the both kidneys were measured by plating the homogenized renal tissue on TSA plates. (A) Mice were challenged intravenously with 1×10⁷ CFUs of USA300. (B) Mice were challenged intraperitoneally with 1×10⁹ CFUs of USA300. The data represent the log₁₀ (CFU/g) means ± SEM. The statistical significance was analyzed with a two-tailed unpaired t test (*: p<0.05, **: p<0.01).