Table 1. Bacterial diversity in the blood of the 22 patients classified as confirmed bBSI based on the results of blood culture and 16S metagenomics.

Patient	Malaria	Prior antibiotics	Survival	Blood culture	16S Metagenomics
					Bacterium 1	Bacterium 2	Bacterium 3	Bacterium 4
1	yes	no	yes		Salmonella enterica
2	yes	no	yes		Salmonella enterica
3	no	no	yes		Salmonella enterica
4	yes	no	yes		Salmonella enterica
5	no	no	yes	Salmonella enterica
6	no	no	yes	Staphylococcus aureus	Staphylococcus aureus
7	no	no	yes	Streptococcus pneumoniae
8	no	Ceftriaxone	yes		Streptococcus pneumoniae
9	no	no	yes		Bordetella pertussis
10	no	no	yes	Neisseria meningitidis
11	no	no	no	Neisseria meningitidis
12	no	Ampicillin	yes		Neisseria meningitides*
13	no	Ampicillin	no		Streptococcus pneumoniae*
14	yes	no	yes	Escherichia coli	Escherichia coli	Salmonella enterica
15	no	no	no	Salmonella enterica	Salmonella enterica	Enterobacter cloacae
16	no	no	unknown	Haemophilus influenzae	Haemophilus influenzae	Salmonella enterica
17	yes	no	yes		Salmonella enterica	Morganella morganii
18	yes	Ampicillin	no	Salmonella enterica	Salmonella enterica	Aeromonas media
19	yes	no	yes		Escherichia coli	Shigella spp.
20	yes	Amoxicillin	no	Escherichia coli	Escherichia coli	Shigella spp.*	Enterobacter aerogenes
21	no	Cotrimoxazole	no	Escherichia coli	Escherichia coli	Shigella spp.*	Rickettsia bellii
22	no	Cotrimoxazole	no	Salmonella enterica	Salmonella enterica	Enterobacter cloacae	Klebsiella spp.	Pantoea agglomerans

* comprises multiple closely related species as detailed in S1 Table.