FIG 1.

Proposed sesquiterpenoid biosynthesis pathway in Atractylodes lancea adapted from Wang et al. (13). Lines ending with a bar indicate the repression of enzymatic activities by inhibitors (mevinolin and fosmidomycin). Acetyl-CoA, acetyl coenzyme A; DXP, 1-deoxy-d-xylulose 5-phosphate; DXR, 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FOS, fosmidomycin; FPP, farnesyl pyrophosphate; GA-3P, glyceraldehyde 3-phosphate; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; HMGR, 3-hydroxy-3-methylglutaryl coenzyme A reductase gene; IPP, isopentenyl diphosphate; MEP, 2-C-methyl-d-erythritol phosphate; MEV, mevinolin; MVA, 3R-mevalonic acid.