FIG 7.

Cohousing with villin-TLR4 mice increases colonic inflammation in WT mice after DSS exposure. (a) Histological inflammatory scores of disease severity of SH-WT and CH-WT mice on day 6 of DSS treatment. (b) Relative levels of TNF-α mRNA expression in the proximal colons of SH-WT and CH-WT mice. (c to f) Fold changes in distal colon explant IL-6, CXCL-10, CCL2, and IL-10 protein secretion levels in CH-WT versus SH-WT mice. *, P < 0.05 by one-tailed Student t test. Mean values ± the standard errors of the means of five or six mice per group are shown.