Table 3.
Effect of TSD on renal SOD, CAT, GSH-Px, and MDA levels in diabetic rats
| Groups | SOD (U/mg prot) | CAT (U/mg prot) | GSH-Px (U/mg prot) | MDA (nmol/mg prot) |
|---|---|---|---|---|
| NC | 211.2±22.1 | 43.28±10.13 | 1.77±0.36 | 2.06±0.25 |
| DC | 151.5±31.0* | 30.19±6.13* | 1.27±0.17* | 3.15±0.36* |
| Met | 152.6±43.5 | 38.12±8.58 | 1.48±0.38 | 2.79±0.54 |
| TSD-40 | 176.7±27.6 | 37.40±2.73** | 1.47±0.43 | 2.80±0.67 |
| TSD-80 | 182.2±16.4** | 39.18±5.30** | 1.60±0.33** | 2.61±0.47** |
| TSD-160 | 195.5±15.5*** | 40.86±3.93*** | 1.75±0.42** | 2.35±0.73** |
Notes: Values are mean ± SD for eight rats in each group.
*
P<0.01 as compared with the normal control group.
**
P<0.05 as compared with the diabetic control group.
***
P<0.01 as compared with the diabetic control group.
Abbreviations: CAT, catalase; GSH-Px, glutathione peroxidase; MDA, malondialdehyde; SOD, superoxide dismutase; NC, normal control group; DC, diabetic control group; Met, metformin hydrochloride group; TSD, total saponin of Dioscorea hypoglaucae Palibin; SD, standard deviation.