Table 4.
Effect of TSD on renal TGF-β1, CTGF, TNF-α, IL-1β, and IL-6 levels in diabetic rats
| Groups | TGF-β1 (ng/mg port) | CTGF (pg/mg port) | TNF-α (pg/mg port) | IL-1β (pg/mg port) | IL-6 (pg/mg port) |
|---|---|---|---|---|---|
| NC | 3.14±0.55 | 83.54±12.03 | 21.63±4.90 | 9.28±1.14 | 12.72±1.45 |
| DC | 5.88±0.46* | 109.81±14.12* | 64.79±10.32* | 18.15±1.72* | 31.42±2.24* |
| Met | 5.12±0.47** | 97.11±15.11** | 55.12±3.89** | 12.92±1.36*** | 22.45±2.13*** |
| TSD-40 | 4.93±0.92** | 96.27±15.56** | 53.37±5.84** | 14.16±1.28** | 27.83±2.97 |
| TSD-80 | 4.81±0.48*** | 92.68±7.05*** | 43.20±5.73*** | 12.47±1.48*** | 25.27±2.49*** |
| TSD-160 | 4.63±0.58*** | 90.88±8.28*** | 36.45±6.43*** | 10.47±1.45*** | 22.36±2.45*** |
Notes: Values are mean ± SD for eight rats in each group.
*
P<0.01 as compared with the normal control group.
**
P<0.05 as compared with the diabetic control group.
***
P<0.01 as compared with the diabetic control group.
Abbreviations: CTGF, connective tissue growth factor; IL-1β, interleukin-1β; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α; TGF-β1, transforming growth factor-β1; NC, normal control group; DC, diabetic control group; Met, metformin hydrochloride group; TSD, total saponin of Dioscorea hypoglaucae Palibin; SD, standard deviation.