Figure 2.

Pathology of the aorta. Aortae were collected from dogs at the ages indicated above the panels and then stained for elastin with Verhoeff’s van Giesen stain, which results in a dark color in the fibers. All images have the intima (I) at the upper left, and the adventitia (A) in the lower right. Lysosomal storage is indicated by the short vertical arrow, and elastin fiber fragmentation is identified with the long horizontal arrow. Low-power images (original magnification ×5) are shown in the top panels, in which the box indicates the region that is shown at high power (original magnification ×20) in the lower panels.